One major concern with topical treatments is that they contain chemicals that are absorbed into the skin. It is not known exactly what effect this has on the body, but there are certainly some risks and side effects from the absorption of topical medications into the body, skin tags treatment are effective against hemorrhoids treatment but also have negative side effects. Some of the more severe side effects include serious problems with organs including the liver, intestines, and eyes. Other documented side effects include severe depression and even suicide in rare cases. These effects are a high price to pay for a face free of acne. There are no harmful chemicals being absorbed into your body. You simply take the B5 vitamin pills just like you would take any other vitamin supplement. Vitamin B5 is water soluble, which makes it impossible to overdose.Some topical medications work well for treating acne, but others do not. Many people spend years of their lives applying topical treatments to their acne with varying levels of success.